A Systematic Review of the Possibility of Determining Age Based on DNA Methylation of the ELOVL2 Gene in Human Samples

Background: In forensic medicine, predicting the age of a victim or suspect can be clue to solving crime. Epigenetics has recently played vital role in prediction medicine. Cytosine methylation at cytosine and guanine separated by phosphate (CpG) sites is well recognized as novel epigenetic marker for estimation. This study aimed summarize information obtained from previous studies determine evaluating DNA ELOVL2 gene. Methods: this systematic review, all related articles published between 2012 2022 were extracted searching reputable scientific databases, such ISI Web Science, Science Direct, PubMed, Scopus. After selecting appropriate articles, full text was prepared fully evaluated researchers. The protocol carried out based on preferred reporting items reviews meta-analyses (PRISMA) statement. Results: Out 307 5 eligible review according protocol. strongest correlation observed 11044644 11044634 chromosome 6 living cases. relationship chronological calculated through above 90% with an approximate error ranging 7.5 10.4. However, multivariate analysis 11044624 6. case, calculation reached approximately 6.9 years. Hence, considering combination multiple improves accuracy reduces percentage. relationships 11044880 11044640 significantly less reported blood samples taken dead those (nearly 64%–78.5%). Conclusion: results indicated that gene could help predict person’s biological age.